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Xavier Garric

Xavier Garric

Professor, Faculty of pharmacy, University of Montpellier

Xavier Garric was born in Nice (France) in 1977. He first received his PharmD degree in 2001 before he obtained his PhD in 2004 from the University of Montpellier I, under the supervision of Doctors Michel Vert and Jean-Pierre Molès in the field of degradable polymeric scaffold in skin engineering. He joined the group of Doctor Michel Vert as an Assistant Professor at the University of Montpellier, in 2005. He was appointed Professor of Polymer Chemistry at the Faculty of Pharmacy in 2013 and became team leader in September 2018. His research interests are focused on biomedical applications of polymers and especially for the design of new drug delivery systems and degradable medical devices.
Part of his recent research is related to the design of an anti-adhesion, self-expanding and degradable medical device for the prevention of intra-uterine adhesions. This work led to the creation of the Womed start-up in 2018 of which he is co-founder and scientific advisor.
Another part of his research focuses on degradable elastomers for tissue engineering applications as the well as the development of new drug eluting system for implantable medical device.
Xavier is co-author of over 46 papers and 5 patents.
He is co-head of the master’s degree in health engineering, he is deputy director of the scientific chemistry department at the University of Montpellier.

Contact:

xavier.garric(a)umontpellier.fr
+33411759693

5 recent publications:

Pinese C, Gagnieu C, Nottelet B, Rondot-Couzin C, Hunger S, Coudane J, Garric X. In vivo evaluation of hybrid patches composed of PLA based copolymers and collagen/chondroitin sulfate for ligament tissue regeneration. J Biomed Mater Res B 2017;105:1778-88.

Guillaume O, Garric X, Lavigne JP, Van Den Berghe H, Coudane J. Multilayer, degradable coating as a carrier for the sustained release of antibiotics: Preparation and antimicrobial efficacy in vitro. J Control Release 2012;162:492-501.   IF 2016 = 7.786

Blanquer S, Guillaume O, Letouzey V, Lemaire L, Franconi F, Paniagua C, Coudane J, Garric X. New magnetic-resonance-imaging-visible poly(epsilon-caprolactone)-based polyester for biomedical applications. Acta Biomater 2012;8:1339-47.  IF 2016 = 6.319

Morille M, Tran Van T, Garric X, Coudane J, Venier-Julienne MC, Montero-Menei C. Microsphere compositions, preparation and method and applications thereof. WO2013144341

Coudane J, Leprince S, Garric X, Paniagua C, Huberlant S, Letouzey V. Composition of diblock and triblock copolymers and the use thereof in the prevention of tissues adhesions. WO2016020613

Long-term in vivo performances of polylactide / iron oxide nanoparticles core-shell fibrous nanocomposites as MRI-visible magneto-scaffolds

Biomat. Sci. XX, XXX–XXX (2021)

 Awada H., Seene S., Laurencin D., Lemaire L., Franconi F., Bernex F., Bethry A., Garric X., Guari Y., Nottelet B.

ABSTRACT

There is a growing interest in magnetic nanocomposites in biomaterials science. In particular, nanocomposites that combine poly(lactide) (PLA) nanofibers and super paramagnetic iron oxide nanoparticles (SPIONs), which can be obtained by either electrospinning of a SPIONs suspension in PLA or by precipitating SPIONs at the surface of PLA, are well documented in the literature. However, these two classical processes yield nanocomposites with altered materials properties, and their long-term in vivo fate and performances have in most cases only been evaluated over short periods of time. Recently, we reported a new strategy to prepare well-defined PLA@SPIONs nanofibers with a quasi-monolayer of SPIONs anchored at the surface of PLA electrospun fibers. Herein, we report on a 6-month in vivo rat implantation study with the aim of evaluating the long-term magnetic resonance imaging (MRI) properties of this new class of magnetic nanocomposites, as well as their tissue integration and degradation. Using clinically relevant T2-weighted MRI conditions, we show that the PLA@SPIONs nanocomposites are clearly visible up to 6 months. We also evaluate here by histological analyses the slow degradation of the PLA@SPIONs, as well as their biocompatibility. Overall, these results make these nanocomposites attractive for the development of magnetic biomaterials for biomedical applications.

Modulation of protein release from penta-block copolymer microspheres European Journal of Pharmaceutics and Biopharmaceutics 152, 175–182 (2020)

European Journal of Pharmaceutics and Biopharmaceutics 152, 175–182 (2020).

Minh-Quan Le, Jean-Christophe Gimel, Xavier Garric, Thao-Quyen Nguyen-Pham, Cédric Paniagua, Jérémie Riou, Marie-Claire Venier-Julienne,

 

ABSTRACT

Releasing a protein according to a zero-order profile without protein denaturation during the polymeric microparticle degradation process is very challenging. The aim of the current study was to develop protein-loaded microspheres with new PLGA based penta-block copolymers for a linear sustained protein release. Lysozyme was chosen as model protein and 40 µm microspheres were prepared using the solid-in-oil-in-water solvent extraction/evaporation process. Two types of PLGA-P188-PLGA penta-block copolymers were synthetized with two PLGA-segments molecular weight (20 kDa or 40 kDa). The resulting microspheres (50P20-MS and 50P40-MS) had the same size, an encapsulation efficiency around 50–60% but different porosities. Their protein release profiles were complementary: linear but non complete for 50P40-MS, non linear but complete for 50P20-MS. Two strategies, polymer blending and microsphere mixing, were considered to match the release to the desired profile. The (1:1) microsphere mixture was successful. It induced a bi-phasic release with a moderate initial burst (around 13%) followed by a nearly complete linear release for 8 weeks. This study highlighted the potential of this penta-block polymer where the PEO block mass ratio influence clearly the Tg and consequently the microsphere structure and the release behavior at 37 °C. The (1:1) mixture was a starting point but could be finely tuned to control the protein release.

In Vivo Evaluation of the Efficacy and Safety of a Novel Degradable Polymeric Film for the Prevention of Intrauterine Adhesions.

Journal of Minimally Invasive Gynecology (2020)

Stéphanie Huberlant, Salomé Leprince, Lucie Allegre, Sophie Warembourg, Isabelle Leteuff, Hubert Taillades, Xavier Garric., Renaud de Tayrac, Vincent Letouzey.

ABSTRACT

To study the safety of a degradable polymeric film (DPF) and its efficacy on reducing the risk of intrauterine-adhesion (IUA) formation in a rat model.A series of case-control studies relying on random allocation, where feasible.The animal models comprised female and male Oncins France Strain A and female Wistar rats.The Oncins France Strain A rats were used for in vivo evaluation of the impact of the DPF on endometrial thickness and its effect on fertility. For in vivo evaluation of the biologic response, 40 Wistar rats were randomly allocated to intervention and control groups, with matched sampling time after surgery. Finally, for the in vivo evaluation of the DPF’s efficacy on IUA prevention, a total of 24 Wistar rats were divided into 3 groups: 1 treated with the DPF, 1 treated with hyaluronic acid gel, and a sham group. The DPF did not have a significant impact on endometrial thickness, and there were no significant differences in the number of conceived or prematurely terminated pregnancies, confirming its noninferiority to no treatment. The DPF did not induce irritation at 5 days and 28 days. Finally, the DPF significantly reduced the likelihood of complete IUA formation compared with hyaluronic acid gel– and sham-implanted animals, where only 27% of the animals had their uterine cavity obliterated compared with 80% and 100%, respectively.The DPF is a safe film that is effective in preventing IUA formation after intrauterine curettage in rats.

Double hydrophilic block copolymers self-assemblies in biomedical applications

Adv. Colloid Interface Sci 283, 102213, (2020)

A. El Jundi, S. Buwalda, Y. Bakkour, X. Garric, B. Nottelet

 

ABSTRACT

Double-hydrophilic block copolymers (DHBCs), consisting of at least two different water-soluble blocks, are an alternative to the classical amphiphilic block copolymers and have gained increasing attention in the field of biomedical applications. Although the chemical nature of the two blocks can be diverse, most classical DHBCs consist of a bioeliminable non-ionic block to promote solubilization in water, like poly(ethylene glycol), and a second block that is more generally a pH-responsive block capable of interacting with another ionic polymer or substrate. This second block is generally non-degradable and the presence of side chain functional groups raises the question of its fate and toxicity, which is a limitation in the frame of biomedical applications. In this review, following a first part dedicated to recent examples of non-degradable DHBCs, we focus on the DHBCs that combine a biocompatible and bioeliminable non-ionic block with a degradable functional block including polysaccharides, polypeptides, polyesters and other miscellaneous polymers. Their use to design efficient drug delivery systems for various biomedical applications through stimuli-dependent self-assembly is discussed along with the current challenges and future perspectives for this class of copolymers.

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