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Jean Coudane

Jean Coudane

Professor emeritus, Faculty of pharmacy, University of Montpellier

Jean is an alumnus of the ENS Cachan, he has passed aggregation in Chemistry before moving to INSA of Rouen as assistant professor in organic chemistry in the Laboratory of Macromolecular Substances, managed by Professor Maréchal. in 1991 he moved at the Faculty of Pharmacy of Montpellier in the CRBA (Research Center on Artificial Biopolymers) team, managed par Dr Michel Vert. From 2007 to 2018 he managed the “Artificial Biopolymers” department of IBMM (Max Mousseron Institute on Biomolecules). His research skills are mainly dedicated to the chemical modifications of biodegradable and biocompatible (co)polymers, especially (co)polyesters, for applications in Health, such as implantable polymeric medical devices or polymeric drug vectors.

Part of his recent research work is dedicated to the synthesis of advanced biomaterials via the functionalization of biodegradable aliphatic (co)polyesters. The main applications are i) in drug delivery and vectorization (multifunctional polycaprolactone-graft-polysaccharides) especially for anticancer activity ii) medical devices and tissue engineering: core and surface modification for X-Rays and IRM-imaging, antibacterial applications…

Jean is co-author of 122 papers and 11 patents.

Contact:

Jean.coudane(a)umontpellier.fr
+33 (0)4 11 75 97 11

5 publications récentes:

Nottelet, B.; Darcos, V.; Coudane, J. Aliphatic Polyesters for Medical Imaging and Theranostic Applications. European Journal of Pharmaceutics and Biopharmaceutics 2015, 97, 350–370. https://doi.org/10.1016/j.ejpb.2015.06.023.

Samad, A. A.; Bethry, A.; Janouskova, O.; Ciccione, J.; Wenk, C.; Coll, J.-L.; Subra, G.; Etrych, T.; Omar, F. E.; Bakkour, Y.; lterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems. Macromolecular Rapid Communications 2018, 39 (3), 1700502. https://doi.org/10.1002/marc.201700502.

Samad, A. A.; Bethry, A.; Koziolová, E.; Netopilík, M.; Etrych, T.; Bakkour, Y.; Coudane, J.; Omar, F. E.; Nottelet, B. PCL–PEG Graft Copolymers with Tunable Amphiphilicity as Efficient Drug Delivery Systems. J. Mater. Chem. B 2016, 4 (37), 6228–6239. https://doi.org/10.1039/C6TB01841F.

Sardo, C.; Nottelet, B.; Triolo, D.; Giammona, G.; Garric, X.; Lavigne, J.-P.; Cavallaro, G.; Coudane, J. When Functionalization of PLA Surfaces Meets Thiol–Yne Photochemistry: Case Study with Antibacterial Polyaspartamide Derivatives. Biomacromolecules 2014, 15 (11), 4351–4362. https://doi.org/10.1021/bm5013772.

Coudane J, Leprince S, Garric X, Paniagua C, Huberlant S, Letouzey V. Composition of diblock and triblock copolymers and the use thereof in the prevention of tissues adhesions. WO2016020613

Polyester-polydopamine copolymers for intravitreal drug delivery: role of polydopamine drug-binding properties on extending drug release

Biomacromolecules XX, XX, (2022)

Floriane Bahuon, Vincent Darcos, Sulabh Patel, Zana Marin, Jean Coudane, Grégoire Schwach, and Benjamin Nottelet

 

PCL-g-PDA drug binding copolymer

ABSTRACT

This work reports on a novel polyester copolymer containing poly(dopamine), a synthetic analogue of natural melanin, evaluated in sustained-release drug delivery system for ocular intravitreal administration of drugs. More specifically, a graft copolymer of poly(ε-caprolactone)-graft-poly(dopamine) (PCL-g-PDA) has been synthesized, and was shown to further extend the drug release benefits of state-of-the-art biodegradable intravitreal implants made of poly(lactide) and poly(lactide-co-glycolide). The innovative biomaterial combines the documented drug-binding properties of melanin naturally present in the eye, with the established ocular tolerability and biodegradation of polyester implants. The PCL-g-PDA copolymer was obtained by a two-step modification of PCL with a final PDA content around 2-3 wt.%, and was fully characterised by SEC, NMR, and DOSY NMR. The thermoplastic nature of PCL-g-PDA allowed its simple processing by hot-melt compression moulding to prepare small implants. The properties of unmodified PCL and PCL-g-PDA implants were studied and compared in terms of thermal properties (DSC), thermal stability (TGA), degradability and in vitro cytotoxicity. PCL and PCL-g-PDA implants exhibited similar degradation properties in vitro and were both stable under physiological conditions over 110 days. Likewise, both materials were non-cytotoxic towards L929 and ARPE-19 cells. The drug-loading and in vitro release properties of the new materials were investigated with dexamethasone (DEX) and ciprofloxacin hydrochloride (CIP) as representative drugs featuring low and high melanin binding affinities, respectively. In comparison to unmodified PCL, PCL-g-PDA implants showed significant extension of drug release most likely because of specific drug-catechol interaction with the PDA moieties of the copolymer. The present study confirms the advantages of designing PDA-containing polyesters as a class of biodegradable and biocompatible thermoplastics that can modulate and remarkably extend drug release kinetics thanks to their unique drug binding properties, especially, but not limited to, for ocular applications.

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Poly(Lactic Acid)-Based Graft Copolymers: Syntheses Strategies and Improvement of Properties for Biomedical and Environmentally Friendly Applications – A Review

Molecules 27, 4135 (2022)

 Jean Coudane , Hélène Van Den Berghe, Julia Mouton, Xavier Garric, Benjamin Nottelet

ABSTRACT

As a potential replacement for petroleum-based plastics, biodegradable bio-based polymers such as poly(lactic acid) (PLA) have received much attention in recent years. PLA is a biodegradable polymer with major applications in packaging and medicine. Unfortunately, PLA is less flexible and has less impact resistance than petroleum-based plastics. To improve the mechanical properties of PLA, PLA-based blends are very often used, but the outcome does not meet expectations because of the non-compatibility of the polymer blends. From a chemical point of view, the use of graft copolymers as a compatibilizer with a PLA backbone bearing side chains is an interesting option for improving the compatibility of these blends, which remains challenging. This review article reports on the various graft copolymers based on a PLA backbone and their syntheses following two chemical strategies: the synthesis and polymerization of modified lactide or direct chemical post-polymerization modification of PLA. The main applications of these PLA graft copolymers in the environmental and biomedical fields are presented.

Performances and behavior of a water-soluble and pH-sensitive polycarboxybetaine used for metal ion recovery

Materials Today Communications 20, 100575, 2019

 

Mouton, J., Kirkelund, G.M., Hassen, Y., Chastagnol, S., Van den Berghe, H., Coudane, J., Turmine, M

 

ABSTRACT

Zwiterionic functional groups give polycarboxybetaines a great ability to chelate copper and their use for metal ions recovery was suggested in previous studies. The use of a water-soluble and pH-sensitive polymer (polycarboxy-ethyl-3-aminocrotonate – PCEAC) was investigated for the removal of copper from aqueous solution. The equilibrium adsorption level was determined as a function of temperature, pH and initial adsorbate concentration. The good fit to the Langmuir model offered various information about copper uptake mechanisms. The maximal adsorption capacities were found to reach 253 ± 11 mg of copper per g of PCEAC at pH=6. The thermodynamic parameters such as free energy, enthalpy and entropy changes for the adsorption of copper were computed to predict the nature of adsorption process. The removal of copper was varying from 2% to 97% depending on pH and initial copper concentration. A particular behavior of PCEAC at pH=4 is discussed and explained by viscosity measurements as a particular conformation of the polymer. The effect of cadmium on copper adsorption was also tested. Some co-adsorption phenomena were observed at low cadmium concentrations ([Cd]/[Cu]≤1), while copper desorption in favor of cadmium adsorption were quantified at higher cadmium concentrations ([Cd]/[Cu]>1).

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Ultrafast in situ forming poly(ethylene glycol)-poly(amido amine) hydrogels with tunable drug release properties via controllable degradation rates

Eur. J. Pharm. Biopharm. 139, 232-239 (2019)

Buwalda S., Bethry A., Hunger S., Kandoussi S., Coudane J., Nottelet B.

ABSTRACT

Fast in situ forming, chemically crosslinked hydrogels were prepared by the amidation reaction between N-succinimidyl ester end groups of multi-armed poly(ethylene glycol) (PEG) and amino surface groups of poly(amido amine) (PAMAM) dendrimer generation 2.0. To control the properties of the PEG/PAMAM hydrogels, PEGs were used with different arm numbers (4 or 8) as well as different linkers (amide or ester) between the PEG arms and their terminal N-succinimidyl ester groups. Oscillatory rheology measurements showed that the hydrogels form within seconds after mixing the PEG and PAMAM precursor solutions. The storage moduli increased with crosslink density and reached values up to 2.3 kPa for hydrogels based on 4-armed PEG. Gravimetrical degradation experiments demonstrated that hydrogels with ester linkages between PEG and PAMAM degrade within 2 days, whereas amide-linked hydrogels were stable for several months. The release of two different model drugs (fluorescein isothiocyanate-dextran with molecular weights of 4·103 and 2·106 g/mol, FITC-DEX4K and FITC-DEX2000K, respectively) from amide-linked hydrogels was characterized by an initial burst followed by diffusion-controlled release, of which the rate depended on the size of the drug. In contrast, the release of FITC-DEX2000K from ester-containing hydrogels was governed mainly by degradation of the hydrogels and could be modulated via the ratio between ester and amide linkages. In vitro cytotoxicity experiments indicated that the PEG/PAMAM hydrogels are non-toxic to mouse fibroblasts. These in situ forming PEG/PAMAM hydrogels can be tuned with a broad range of mechanical, degradation and release properties and therefore hold promise as a platform for the delivery of therapeutic agents.