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Vincent Darcos

Vincent Darcos

Research engineer, Faculty of pharmacy, University of Montpellier

Vincent is a CNRS Research Engineer at the Institute of Biomolecules Max Mousseron (IBMM). After defending his PhD in the field of organic chemistry (2000, University of Bordeaux), he joined the group of Prof. Dave Haddleton at the University of Warwick in UK (Marie-Curie Fellowship, 2000-2002). Then, he moved for a one-year post-doctoral fellow at the University of Bordeaux (LCPO) in the group of Dr. Yves Gnanou (Rhodia funding). In 2004, he joined the IBMM and defended his HDR in 2017. His research interests focus in the field of macromolecular engineering in order to develop original polymeric biomaterials for health applications.
His research interests focus in the field of macromolecular engineering in order to develop original polymeric biomaterials for health applications. Some of his current projects focus on the development of new drug delivery systems, implantable medical devices for bone reconstruction, or bioconjugates for medical diagnosis. He is the co-author of 42 publications and 2 patents in the field of polymer chemistry.
He’s in charge of the “polymer” facility of the SynBio3 platform (IBISA label & ISO9001 certification) dedicated to assist the development of research programs in life science providing biomolecules and polymers of biological and pharmaceutical interest.

Contact:

vincent.darcos(a)umontpellier.fr
(+33) 0411759704

5 recent publications:

El Habnouni, S.; Darcos, V.; Coudane, J., Synthesis and Ring Opening Polymerization of a New Functional Lactone, alpha-Iodo-epsilon-caprolactone: A Novel Route to Functionalized Aliphatic Polyesters. Macromolecular Rapid Communications 2009, 30 (3), 165-169.

Bakkour, Y.; Darcos, V.; Li, S. M.; Coudane, J., Diffusion ordered spectroscopy (DOSY) as a powerful tool for amphiphilic block copolymer characterization and for critical micelle concentration (CMC) determination. Polymer Chemistry 2012, 3 (8), 2006-2010.

Coumes, F.; Huang, C. Y.; Huang, C. H.; Coudane, J.; Domurado, D.; Li, S. M.; Darcos, V.; Huang, M. H., Design and Development of Immunomodulatory Antigen Delivery Systems Based on Peptide/PEG-PLA Conjugate for Tuning Immunity. Biomacromolecules 2015, 16 (11), 3666-3673.

Younis, M.; Darcos, V.; Paniagua, C.; Ronjat, P.; Lemaire, L.; Nottelet, B.; Garric, X.; Bakkour, Y.; El Nakat, J. H.; Coudane, J., MRI-visible polymer based on poly(methyl methacrylate) for imaging applications. Rsc Advances 2016, 6 (7), 5754-5760.

Coumes, F.; Beaute, L.; Domurado, D.; Li, S.; Lecommandoux, S.; Coudane, J.; Darcos, V., Self-assembly of well-defined triblock copolymers based on poly(lactic acid) and poly(oligo(ethylene glycol) methyl ether methacrylate) prepared by ATRP. RSC Advances 2016, 6 (58), 53370-53377

Self-assembly of well-defined triblock copolymers based on poly(lactic acid) and poly(oligo(ethylene glycol) methyl ether methacrylate) prepared by ATRP

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 RSC Adv. 6, 53370–53377 (2016)

Coumes, F., Beaute, L., Domurado, D., Li, S., Lecommandoux, S., Coudane, J. & Darcos, V.

ABSTRACT

Self-assembly of a series of amphiphilic poly(oligo(ethylene glycol) methyl ether methacrylate)-block-poly(lactic acid)-block-poly(oligo(ethylene glycol) methyl ether methacrylate) (P(OEGMA)-b-PLLA-b-P(OEGMA)) copolymers was investigated. The copolymers were synthesized by a combination of ring-opening polymerization (ROP) of L-lactide and atom transfer radical polymerization (ATRP) of oligo ethylene glycol methyl ether methacrylate (OEGMA). The resulting brush-like triblock copolymers were characterized by 1H NMR and size exclusion chromatography. Self-assembly behavior of the copolymers in deionized water was investigated by fluorescence spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM). The critical aggregation concentration ranged from 50 to 160 mg L−1 depending on the composition. The diameter of the nanoparticles (NPs) was determined by DLS and TEM. Images showed that these nano-sized objects displayed spherical and worm-like morphology with a length increasing with the hydrophilic content. Preliminary studies of drug loading and drug release with a water-insoluble model drug, namely curcumin, showed that these NPs are potential candidates for drug delivery carriers.

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MRI-visible polymer based on poly(methyl methacrylate) for imaging applications

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RSC Adv. 6, 5754–5760 (2016).

Younis, M., Darcos, V., Paniagua, C., Ronjat, P., Lemaire, L., Nottelet, B., Garric, X., Bakkour, Y., El Nakat, J. H. & Coudane, J.

 

ABSTRACT

Macromolecular contrast agents are very attractive to afford efficient magnetic resonance imaging (MRI) visualization of implantable medical devices. In this work, we report on the grafting of a Gd-based DTPA contrast agent onto a poly(methyl methacrylate) derivative backbone by combining free radical polymerization and copper-catalyzed azide-alkyne cycloaddition (CuAAC). Using free radical polymerization, poly(methyl methacrylate-co-propargyl methacrylate) copolymers were prepared with a control of the ratio in propargyl methacrylate monomer units. The synthesis of a new azido mono-functionalized DTPA ligand was also reported and characterized by 1H NMR and mass spectroscopy. After complexation with gadolinium, this ligand has been grafted on the polymer backbone by click chemistry reaction. The obtained macromolecular contrast agent was then coated on a polypropylene mesh using the airbrushing technique and the mesh was assessed for MRI visualization at 7 teslas. The polymeric contrast agent was also tested for cytocompatibility and stability to assess its suitability for biomedical applications.

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MRI-visible nanoparticles from hydrophobic gadolinium poly(ε-caprolactone) conjugates

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Polymer 56, 135–140 (2015)

Porsio, B., Lemaire, L., El Habnouni, S., Darcos, V., Franconi, F., Garric, X., Coudane, J. & Nottelet, B

 

ABSTRACT

In this work we report on the synthesis of two hydrophobic and degradable gadolinium poly(ε-caprolactone) conjugates and their use for the preparation of MRI-visible nanoparticles intended for diagnosis applications. Advantage has been taken from functional poly(ε-caprolactone)s (PCL) bearing propargyl (PCL-yne) or amine groups (P(CL-co-NH2VL)) to yield conjugates by following two strategies. In a first approach, an azido-chelate of gadolinium (Gd(III)) has been conjugated by CuAAC to PCL-yne to yield a polymeric chelate containing 2.6 wt% of Gd(III). In a second approach, a dianhydride Gd(III)-ligand was reacted with P(CL-co-NH2VL) to yield, after complexation with Gd(III) salts, a polymeric chelate containing 15.4 wt% of Gd(III). The polymers biocompatibility was assessed against L929 fibroblasts. In a second part, advantage was taken from the PCLs conjugates hydrophobicity to easily prepare by nanoprecipitation nanoparticles with diameters ranging from 120 to 170 nm. The nanoparticles MRI-visibility was then evaluated and confirmed under the spin-echo and the clinically relevant gradient-echo MRI sequences.

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Design and Development of Immunomodulatory Antigen Delivery Systems Based on Peptide/PEG-PLA Conjugate for Tuning Immunity

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Biomacromolecules 16, 3666–3673 (2015)

Coumes, F., Huang, C.-Y., Huang, C.-H., Coudane, J., Domurado, D., Li, S., Darcos, V. & Huang, M.-H.

 

ABSTRACT

Cancer vaccines are considered to be a promising tool for cancer immunotherapy. However, a well-designed cancer vaccine should combine a tumor-associated antigen (TAA) with the most effective immunomodulatory agents and/or delivery system to provoke intense immune responses against the TAA. In the present study, we introduced a new approach by conjugating the immunomodulatory molecule LD-indolicidin to the hydrophilic chain end of the polymeric emulsifier poly(ethylene glycol)-polylactide (PEG-PLA), allowing the molecule to be located close to the surface of the resulting emulsion. A peptide/polymer conjugate, named LD-indolicidin–PEG-PLA, was synthesized by conjugation of the amine end-group of LD-indolicidin to the N-hydroxysuccinimide-activated carboxyl end-group of PEG. As an adjuvant for cancer immunotherapeutic use, TAA vaccine candidate formulated with the LD-indolicidin–PEG-PLA-stabilized squalene-in-water emulsion could effectively help to elicit a T helper (Th)1-dominant antigen-specific immune response as well as antitumor ability, using ovalbumin (OVA) protein/EG7 cells as a TAA/tumor cell model. Taken together, these results open up a new approach to the development of immunomodulatory antigen delivery systems for vaccine adjuvants and cancer immunotherapy technologies.

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