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Jean Coudane

Jean Coudane

Professor emeritus, Faculty of pharmacy, University of Montpellier

Jean is an alumnus of the ENS Cachan, he has passed aggregation in Chemistry before moving to INSA of Rouen as assistant professor in organic chemistry in the Laboratory of Macromolecular Substances, managed by Professor Maréchal. in 1991 he moved at the Faculty of Pharmacy of Montpellier in the CRBA (Research Center on Artificial Biopolymers) team, managed par Dr Michel Vert. From 2007 to 2018 he managed the “Artificial Biopolymers” department of IBMM (Max Mousseron Institute on Biomolecules). His research skills are mainly dedicated to the chemical modifications of biodegradable and biocompatible (co)polymers, especially (co)polyesters, for applications in Health, such as implantable polymeric medical devices or polymeric drug vectors.

Part of his recent research work is dedicated to the synthesis of advanced biomaterials via the functionalization of biodegradable aliphatic (co)polyesters. The main applications are i) in drug delivery and vectorization (multifunctional polycaprolactone-graft-polysaccharides) especially for anticancer activity ii) medical devices and tissue engineering: core and surface modification for X-Rays and IRM-imaging, antibacterial applications…

Jean is co-author of 122 papers and 11 patents.

Contact:

Jean.coudane(a)umontpellier.fr
+33 (0)4 11 75 97 11

5 publications récentes:

Nottelet, B.; Darcos, V.; Coudane, J. Aliphatic Polyesters for Medical Imaging and Theranostic Applications. European Journal of Pharmaceutics and Biopharmaceutics 2015, 97, 350–370. https://doi.org/10.1016/j.ejpb.2015.06.023.

Samad, A. A.; Bethry, A.; Janouskova, O.; Ciccione, J.; Wenk, C.; Coll, J.-L.; Subra, G.; Etrych, T.; Omar, F. E.; Bakkour, Y.; lterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems. Macromolecular Rapid Communications 2018, 39 (3), 1700502. https://doi.org/10.1002/marc.201700502.

Samad, A. A.; Bethry, A.; Koziolová, E.; Netopilík, M.; Etrych, T.; Bakkour, Y.; Coudane, J.; Omar, F. E.; Nottelet, B. PCL–PEG Graft Copolymers with Tunable Amphiphilicity as Efficient Drug Delivery Systems. J. Mater. Chem. B 2016, 4 (37), 6228–6239. https://doi.org/10.1039/C6TB01841F.

Sardo, C.; Nottelet, B.; Triolo, D.; Giammona, G.; Garric, X.; Lavigne, J.-P.; Cavallaro, G.; Coudane, J. When Functionalization of PLA Surfaces Meets Thiol–Yne Photochemistry: Case Study with Antibacterial Polyaspartamide Derivatives. Biomacromolecules 2014, 15 (11), 4351–4362. https://doi.org/10.1021/bm5013772.

Coudane J, Leprince S, Garric X, Paniagua C, Huberlant S, Letouzey V. Composition of diblock and triblock copolymers and the use thereof in the prevention of tissues adhesions. WO2016020613

Performances and behavior of a water-soluble and pH-sensitive polycarboxybetaine used for metal ion recovery

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Materials Today Communications 20, 100575, 2019

 

Mouton, J., Kirkelund, G.M., Hassen, Y., Chastagnol, S., Van den Berghe, H., Coudane, J., Turmine, M

 

ABSTRACT

Zwiterionic functional groups give polycarboxybetaines a great ability to chelate copper and their use for metal ions recovery was suggested in previous studies. The use of a water-soluble and pH-sensitive polymer (polycarboxy-ethyl-3-aminocrotonate – PCEAC) was investigated for the removal of copper from aqueous solution. The equilibrium adsorption level was determined as a function of temperature, pH and initial adsorbate concentration. The good fit to the Langmuir model offered various information about copper uptake mechanisms. The maximal adsorption capacities were found to reach 253 ± 11 mg of copper per g of PCEAC at pH=6. The thermodynamic parameters such as free energy, enthalpy and entropy changes for the adsorption of copper were computed to predict the nature of adsorption process. The removal of copper was varying from 2% to 97% depending on pH and initial copper concentration. A particular behavior of PCEAC at pH=4 is discussed and explained by viscosity measurements as a particular conformation of the polymer. The effect of cadmium on copper adsorption was also tested. Some co-adsorption phenomena were observed at low cadmium concentrations ([Cd]/[Cu]≤1), while copper desorption in favor of cadmium adsorption were quantified at higher cadmium concentrations ([Cd]/[Cu]>1).

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Ultrafast in situ forming poly(ethylene glycol)-poly(amido amine) hydrogels with tunable drug release properties via controllable degradation rates

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Eur. J. Pharm. Biopharm. 139, 232-239 (2019)

Buwalda S., Bethry A., Hunger S., Kandoussi S., Coudane J., Nottelet B.

ABSTRACT

Fast in situ forming, chemically crosslinked hydrogels were prepared by the amidation reaction between N-succinimidyl ester end groups of multi-armed poly(ethylene glycol) (PEG) and amino surface groups of poly(amido amine) (PAMAM) dendrimer generation 2.0. To control the properties of the PEG/PAMAM hydrogels, PEGs were used with different arm numbers (4 or 8) as well as different linkers (amide or ester) between the PEG arms and their terminal N-succinimidyl ester groups. Oscillatory rheology measurements showed that the hydrogels form within seconds after mixing the PEG and PAMAM precursor solutions. The storage moduli increased with crosslink density and reached values up to 2.3 kPa for hydrogels based on 4-armed PEG. Gravimetrical degradation experiments demonstrated that hydrogels with ester linkages between PEG and PAMAM degrade within 2 days, whereas amide-linked hydrogels were stable for several months. The release of two different model drugs (fluorescein isothiocyanate-dextran with molecular weights of 4·103 and 2·106 g/mol, FITC-DEX4K and FITC-DEX2000K, respectively) from amide-linked hydrogels was characterized by an initial burst followed by diffusion-controlled release, of which the rate depended on the size of the drug. In contrast, the release of FITC-DEX2000K from ester-containing hydrogels was governed mainly by degradation of the hydrogels and could be modulated via the ratio between ester and amide linkages. In vitro cytotoxicity experiments indicated that the PEG/PAMAM hydrogels are non-toxic to mouse fibroblasts. These in situ forming PEG/PAMAM hydrogels can be tuned with a broad range of mechanical, degradation and release properties and therefore hold promise as a platform for the delivery of therapeutic agents.

Reversibly core-crosslinked PEG-P(HPMA) micelles: Platinum coordination chemistry for competitive-ligand-regulated drug delivery

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J. Colloid Interface Sci. 535, 505–515 (2019)

Buwalda, S., Nottelet, B., Bethry, A., Kok, R. J., Sijbrandi, N. & Coudane, J.

ABSTRACT

Hypothesis. The presence of pendant thioether groups on poly(ethylene glycol)-poly(N(2-hydroxypropyl) methacrylamide) (PEG-P(HPMA)) block copolymers allows for platinum-mediated coordinative micellar core-crosslinking, resulting in enhanced micellar stability and stimulus-responsive drug delivery.

Experiments. A new PEG-P(HPMA) based block copolymer with pendant 4-(methylthio)benzoyl (MTB) groups along the P(HPMA) block was synthesized by free radical polymerization of a novel HPMA-MTB monomer using a PEG based macro-initiator. As crosslinker the metal-organic linker [ethylenediamineplatinum(II)]2+ was used, herein called Lx, which is a coordinative linker molecule that has been used for the conjugation of drug molecules to a number of synthetic or natural carrier systems such as hyperbranched polymers and antibodies.

Findings. The introduction of Lx in the micellar core results in a smaller size, a lower critical micelle concentration and a better retention of the hydrophobic drug curcumin thanks to coordination bonds between the central platinum atom of Lx and thioether groups on different polymer chains. The drug release from Lx crosslinked micelles is significantly accelerated under conditions mimicking the intracellular environment due to competitive coordination and subsequent micellar de-crosslinking. Because of their straightforward preparation and favorable drug release characteristics, core-crosslinked Lx PEG-P(HPMA) micelles hold promise as a versatile nanomedicine platform.

Direct Photomodification of Polymer Surfaces: Unleashing the Potential of Aryl-Azide Copolymers

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 Adv. Funct. Mater. 28, 1800976 (2018)

Schulz, A., Stocco, A., Bethry, A., Lavigne, J.-P., Coudane, J. & Nottelet, B.

ABSTRACT

The possibility to impart surface properties to any polymeric substrate using a fast, reproducible and industrially friendly procedure, without the need for surface pre-treatment, is highly sought after. This is in particular true in the frame of antibacterial surfaces to hinder the threat of biofilm formation. In this study we demonstrate the potential of aryl-azide polymers for photo-functionalization and the importance of the polymer structure for an efficient grafting. The strategy is illustrated with a UV-reactive hydrophilic poly(2-oxazoline) based copolymer, which can be photografted onto any polymer substrate that contains carbon-hydrogen bonds to introduce antifouling properties. Through detailed characterization it is demonstrated that the controlled spatial distribution of the UV-reactive aryl-azide moieties within the poly(2-oxazline) structure, in the form of pseudo gradient copolymers, ensures higher grafting efficacy than other copolymer structures including block copolymers. Furthermore, it is found that the photografting results in a covalently bound layer, which is thermally stable and causes a significant anti-adherence effect and biofilm reduction against E. coli and S. epidermidis strains while remaining non-cytotoxic against mouse fibroblasts.

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