Direct synthesis of peptide-containing silicone. A new way for bioactive materials

ABSTRACT

A simple and efficient way to synthesize peptide-containing silicone materials is described. Silicone oils containing a chosen ratio of bioactive peptide sequences were prepared by acid-catalyzed copolymerization of dichlorodimethylsilane, hybrid dichloromethyl peptidosilane and either Si-vinyl or Si-H functionalized monomers. Functionalized silicone oils were first obtained and then after hydrosilylation cross-linking, bioactive PDMS based materials were straightforward obtained. The introduction of an antibacterial peptide yields PDMS materials showing an interesting activity against Staphylococcus Aureus. In the same way, RGD ligands-containing PDMS demonstrated improved cell adhesion properties. This generic method was fully compatible with the stability of peptides and thus opened the way to the synthesis of a wide range of biologically active silicones.