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Abdeslam El Ghzaoui

Abdeslam El Ghzaoui

Associate Professor, Faculty of Pharmacy, University of Montpellier

Abdeslam graduated in chemical physics at the Universtiy of Montpellier (France). After defending his PhD in the field chemical physics at the Universtiy of Montpellier (1997), he  worked for the C.E.A (Commissariat à l’énergie atomique) in the field of radionuclides solubilisation in micellar and physical hydrogel systems. Then, he joined the C.R.P.P. (Centre de recherche Paul Pascal) (Bordeaux, France) as a post-doc to work on Dendrimers and their supramolecular nanostructures. In 2002, he became Associate Professor at the Faculty of Pharmacy at University of Montpellier and joined the Department of Artificial Biopolymers of IBMM of Prof. Michel Vert.  His research activities focus on the rheology of nano and mesostructures biomaterials obtained from natural and synthetic biopolymers. He also works on interfaces in colloidal systems such as the drug solubilisation in polymer micelles and hydrogels.

Contact:

abdeslam.el-ghzaoui(a)umontpellier.fr
+33(0)4-11-75-96-79

5 recent publications:

A. Mouri, P. Legrand, A. El Ghzaoui, C. Dorandeu, J.-M. Devoisselle
Formulation, physicochemical characterization and stability study of lithium-loaded microemulsion system, International Journal of Pharmaceutics, 2016, 502, 117.

X. Wu, A. El Ghzaoui, and S. Li
Anisotropic Self-Assembling Micelles Prepared by the Direct Dissolution of PLA/PEG Block Copolymers with a High PEG Fraction. Langmuir, 2011, 27, 8000.

A. El Ghzaoui, F. Gauffre, A-M. Caminade, J. P. Majoral, and H. Lannibois-Drean
Self-Assembly of Water-Soluble Dendrimers into Thermoreversible Hydrogels and Macroscopic Fibers, Langmuir, 2004, 20, 9348.

Y. Kadam, C. Pochat-Bohatier, J. Sanchez, A. El Ghzaoui
Modulating Viscoelastic Properties of Physically Cross linked Self-Assembled Gelatin Hydrogels through Optimized Solvent Conditions.
Journal of dispersion science and technology, 2015, 36, 1349.

X. Wu, S. Li, A. El Ghzaoui,
Effects of stereocomplexation on the physicochemical behavior of PLA/PEG block copolymers in aqueous solution, Journal of polymer science part B-polymer physics, 2012, 50, 1352.

Formulation, physicochemical characterization and stability study of lithium-loaded microemulsion system

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Int. J. Pharm. 502, 117–124 (2016)

Mouri, A., Legrand, P., El Ghzaoui, A., Dorandeu, C., Maurel, J. C. & Devoisselle, J.-M.

ABSTRACT

Lithium biocompatible microemulsion based on Peceol®, lecithin, ethanol and water was studied in attempt to identify the optimal compositions in term of drug content, physicochemical properties and stability. Lithium solubilization in microemulsion was found to be compatible with a drug-surfactant binding model. Lithium ions were predominantly solubilized within lecithin head group altering significantly the interfacial properties of the system. Pseudo-ternary phase diagrams of drug free and drug loaded microemulsions were built at constant ethanol/lecithin weight ratio (40/60). Lithium loaded microemulsion has totally disappeared in the Peceol® rich part of phase diagram; critical fractions of lecithin and ethanol were required for the formation of stable microemulsion. The effect of lithium concentration on the properties and physical stability of microemulsions were studied using microscopy, Karl Fischer titrations, rheology analyses, conductivity measurements and centrifugation tests. The investigated microemulsions were found to be stable under accelerated storage conditions. The systems exhibited low viscosity and behaved as Newtonian fluid and no structural transition was shown.

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Development of pharmaceutical clear gel based on Peceol (R), lecithin, ethanol and water: Physicochemical characterization and stability study

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J. Colloid Interface Sci. 457, 152–161, (2015)

Mouri, A., Diat, O., Lerner, D. A., El Ghzaoui, A., Ly I., Dorandeu C.,  Maurel, J.-C., Devoisselle, J.-M., Dorandeu, C.,  Legrand, P.

ABSTRACT

The phase behavior of the four-components Peceol®/lecithin/ethanol/water system has been studied in a part of the phase diagram poor in water and varying the lecithin/Peceol® ratio. Using several complementary techniques such as Karl Fischer titration, rheology, polarized microscopy and SAXS measurements several nanostructures of the complex systems were identified. W/O microemulsion (L2) as well as an inverted hexagonal (H2) liquid-crystal phase were studied. The analysis of the different phase transitions allows us to understand the effect of lecithin on the water solubilization efficiency of this clear gel and to show its pharmaceutical interest among lecithin organogels.

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Modulating Viscoelastic Properties of Physically Cross linked Self-Assembled Gelatin Hydrogels through Optimized Solvent Conditions

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J. Dispers. Sci. Technol. 36, 1349-1356, (2015)

Kadam, K., Pochat-Bohatier C., Sanchez J., El Ghzaoui A.

 

ABSTRACT

In this work, an experimental study was conducted on two different types of gelatin from mammalian sources, type A, derived from acid-cured tissue of porcine skin and type B, from lime-cured tissue of bovine skin. The effect of temperature, pH, and ionic strength on viscoelastic properties of gelatin hydrogels was carried out in order to determine the conformational characteristics and phase transition (sol-gel transition temperatures, Tm – melting temperature and T-g- gelling temperature) behavior. The detailed investigation on gelation behavior of gelatin hydrogels was performed with rheological measurements in the temperature range of 5-35 degrees C as a function of pH with and without added salt (NaCl) and gelation transition temperatures evaluated for all these conditions. Both types of gelatins show polyelectrolyte effect with added NaCl (0.001-0.1 M) for the studied pH conditions (pH 1 or pH 7). The maximum in the gelation properties was observed at lower NaCl concentrations (0.001 M for type-A and 0.01 M for type-B). The significant improvement in gelation behavior with optimum pH or amount of added NaCl imparts longer stability to gelatin hydrogels, which were reflected in degradation study. This work establishes a relationship between gelatin properties and the values of temperatures and solvent conditions (pH and NaCl concentrations), thus providing insight on how to control the stability and melting of gelatin gels in view of their potential application in the biomedical and food industries.

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Water solubilization capacity of pharmaceutical microemulsions based on Peceol (R), lecithin and ethanol.

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Int. J. Pharm. 475, 324–334 (2014).

Mouri, A., Diat, O., Lerner, D. A., El Ghzaoui, A., Ajovalasit, A., Dorandeu, C., Maurel, J.-C., Devoisselle, J.-M. & Legrand, P.

 

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